Showing posts with label pet toxins. Show all posts
Showing posts with label pet toxins. Show all posts

Friday, March 29, 2013

#FurbabyFridays Warning About Easter Lily Toxicity in Cats


For those of you who have visited with me this entire month, you may have noticed a trend. I've been working my way through some of the common toxins that I've seen with my patients. Since this weekend many will celebrate the Easter holiday, I decided today's spotlight toxin should focus on one that can happen any time during the year and not just now.

Easter Lily
Lily toxicity is unfortunately a very common presentation to veterinary hospitals all over the country. People receive beautiful bouquets of flowers from loved ones and secret admirers all the time. Because lilies come in a variety of types and colors, they are a popular addition to these gifts. Unfortunately, these gifts of love and admiration can be deadly for our feline family members.



Star Gazer Lily


Easter lilies, tiger lily, Japanese Show lily, some species of day lily and certain other members of the Liliaceae family can cause kidney failure in cats. All parts of these lilies are considered toxic and consuming even tiny amounts can be life threatening. Many people are not aware of the dangers these kinds of lilies pose so if you're expecting a florist to warn you about the potential hazard, good luck with that. As more and more people learn about it and help to educate others, one day we will see a decline in cats admitted to emergency hospitals on death's door.




The exact toxin so far has not been identified. Just like with the grape and raisin, we are left stumped as to why it happens. We do know the toxin is water soluble and kidney damage occurs within 24 to 72 hours of ingestion of even just a few bits of a leaf or flower petal.

There are no known diagnostic tests to check for lily toxicity. The tests performed by your veterinarian center on checking the function of your pet's kidneys. Treatment must be done early on in order to be successful. Just like with most ingested toxins, the emptying of the stomach contents is recommended if it's within 2 to 4 hours of ingestion of the plant. Activated charcoal, IV fluids for at least 24 hours and other supportive care is needed to ensure the patient recovers. If left untreated, kidney failure usually begins within 2 to 4 days. By this point there are very few treatment options left and the death rate from lily toxicity is very high.

What are the common signs of lily poisoning?

These early signs often develop within the first 6 to 12 hours of exposure
  • vomiting
  • inappetance
  • lethargy
  • dehydration
Left untreated, the signs worsen as kidney failure develops
  • not urinating at all or urinating too frequently
  • not drinking at all or excessive thirst
  • walking drunk
  • diorientation
  • tremors
  • seizures
  • death
Once again...THERE IS NO ANTIDOTE for lily poisoning. Prompt veterinary attention is necessary.

What about other types of lilies?

Peace Lily
Not all lilies cause kidney failure but there are some that are mildly poisonous. These kinds contain oxalate crystals that irritate the mouth, tongue, pharynx and esophagus. With these, you will see minor drooling. Even so, it's better to be safe than sorry with ingestion of lilies of any kind.  Examples of these less toxic lilies include
  • Peace Lily
  • Peruvian Lillies
  • Calla lilies



Add Cala Lilies


The take home message here is to avoid having lilies of any kind around your cats. If you are planning on sending a flower arrangement to someone and you know they have cats, ask the florist to use alternatives to lilies. If you suspect your cats have been munching on any part of the lily that does make it into your home, consult with your veterinarian IMMEDIATELY.  If you see any of the signs discussed above, seek veterinary help ASAP. Time is your enemy in this situation. 

~Dr. Tammy


Additional resources that can be helpful

Friday, February 15, 2013

Dr. Tammy Talks About Grape and Raisin Toxicity for #FurbabyFridays


The day got away from me and I nearly forgot to continue with the next part in the common pet toxin series. Last week, garlic and onions took center stage. This week it's grapes and their shriveled sweet counterparts, raisins.

For many years people have used raisins for training treats in all species, especially dogs. It wasn't until 1989 that the veterinary community started to notice a trend. Around that time, more cases of acute kidney failure were being reported in dogs who had either eaten grapes or raisins. At that time the Animal Poison Control Center didn't have any idea why these dogs were getting sick from these kinds of fruit, but they continued to collect the data and search for any and all common factors and trends. To this day, there haven't been any breakthroughs. Whether the grapes were fresh from the vine, sold in stores as organic or not, with or without seeds, or different colors, the outcome was still the same. SOME dogs who ingested enough grapes and raisins for their body developed kidney failure. A few never recovered. Most made it after aggressive intervention and therapy.

Anywhere from 24 hours to several days after the dogs eat grapes or raisins, veterinarians can detect abnormalities in blood tests. Consistently they would find hypercalcemia (elevated calcium levels), elevated blood urea nitrogen, creatinine and phosphorus. These all point to damage to the kidneys. At this point in time, you can't tell if it's irreversible. The animal must be treated with aggressive fluid therapy to help flush the kidneys and maybe the remaining toxin out of the system.

How can you tell if your dog ate grapes or raisins?



Many will have vomiting within a few hours of ingesting them and have bits or whole fruit present in the vomitus. This kind of evidence definitely helps you determine that your pet needs immediate attention by your veterinarian or local veterinary emergency facility.

If you are in the majority of pet owners, you won't see the initial symptoms but would see anorexia and probably diarrhea. Fast on the heals of that would find the dogs developing lethargy and signs of abdominal pain: stretching out like in a praying or downward dog yoga position. There have been cases where these symptoms have gone on for several days or even weeks.

Why do these dog's become so ill?

No one knows. They've tested for pesticides, heavy metals, mycotoxins (fungal contaminants)...anything that could be a common link between the cases and still NOTHING. All tests have come up negative. Even grapes that have been privately grown without any insecticides, fertilizers or antifungals used on the plants or fruit have been involved in these toxicities.

Is any amount of grapes or raisins considered below the toxic level?

At this point in time, that is also an unknown. We do know that since raisins are dried grapes and felt to be more concentrated, it would take less raisins to make a dog sick. Researchers have come up with some general guidelines, but again all patients are different. They don't all follow the "rules" so any grape or raisin ingestion is best to be avoided.

It looks like 0.5 OUNCES of grapes per pound of the dog's body weight would be enough to cause symptoms. So it would take 5 ounces of grapes to make a 10 pound dog sick. It would take as little as 2 ounces of raisins or one of those little snack size packages to make the same sized dog ill.


What about other animals? Do they get the same symptoms?

So far it's only seen in dogs, but when I practiced in Michigan and still saw ferrets (before I became highly allergic!) we did start telling those owners to not feed grapes or raisins to them just to be safe. I never had a confirmed case of kidney failure from grapes or raisins in a ferret and haven't seen any in the literature. 

As for cats...well, they make up their own rules about everything. Most cats won't eat a grape or raisin if their life depended on it. Unfortunately so many other things end up being toxic to cats that it's just best to NOT have these fruits out for them to try. The feline doesn't need any other excuse to get kidney failure than it already has! Sure, we can giggle about that, but it's true. Cats are so much more sensitive to toxicities than their canine counterparts. 

So just keep the grapes and raisins for the humans in your family and away from your furbabies. This includes juices, cookies, fruit bars, cakes and breads with these fruits too. Wine is another story altogether and will be covered in alcohol toxicity.  For now, I'll leave you with a way your furry friends CAN enjoy raisins. 
Enjoy!

Dr. Tammy




Friday, February 8, 2013

Pet Toxins Part II: Garlic and Onions on #FurbabyFridays



Welcome back to Furbaby Fridays. Today I'm continuing the series on common pet toxins. Last week I talked about marijuana and this week I'm covering my all time faves...garlic and onions.  Many folks know that onions are toxic but these same folks refuse to jump off the supplemental garlic band wagon. Too often I've had to correct that Old Wive's Tale that garlic repels fleas.

It doesn't and it never has. It doesn't repel ticks, lice or any other blood sucking or biting parasite.

Now that's out of the way. Let's get on with the discussion shall we?

Garlic and onions come from the same species of plants. Allium species contain a wide variety of toxins called organosulfioxides. Through chewing or other trauma to the plant, these turn into a mixture of sulfur containing compounds. This is how the plants get their characteristic odors and flavors as well as their pharmacological effects...how they can affect the body. They are readily absorbed through the gastrointestinal tract and then metabolized into other chemicals that are considered to be highly reactive oxidative agents.  This toxicity is not diminished through cooking or if the plants spoil.  For our discussion, I'll just stick to the "usual suspects" and not discuss the wild onions and garlic plants.

I know some of you are shaking your head right now. You want to argue with me that if garlic is so toxic, why is it in some pet foods, recommended by some veterinarians as helpful to pets? Let me start off with this statement:

"ALL ingested garlic/onion will cause some degree of hemolysis in dogs and cats—it's only when sufficient red blood cells have been damaged to alter the overall oxygen carrying capacity of the blood and/or to cause hemoglobinuria (dark red-brown urine) that the toxicosis becomes clinically evident."  Sharon Gwaltney-Brant DVM, PhD  Diplomate, American Board of Veterinary Toxicology

 What the good doctor above is saying is that even the very small amounts used in making these pet foods and maybe in your left over beef stew will cause damage to the animals red blood cells. If the animal is otherwise healthy, it's body will end up destroying the affected cells and creating new ones every three days...like usual.  Unfortunately, if there is any other medical condition that has already caused problems, the body may not be able to keep up with the repair. So even in these patients, the very small amounts are a big NO NO.

DO NOT FEED THIS TO YOUR PETS!!!
Garlic is FIVE TIMES more toxic than it's family member the onion. The toxic does of onions is 5 grams of onions per kg in weight of the animal. Garlic is 1gram per kg of body weight. That seems like a lot until you find out that 1 TEASPOON equals 5 grams. So 1 teaspoon of raw onions or raw/fresh garlic each weigh five grams.  Another thing to note here is that  garlic POWDER is 2 to 2.5x more potent than fresh garlic. So  if you cook with 1 teaspoon of garlic powder you are using the equivalent to 12.5 grams of fresh garlic.  Hang onto your hats folks: cooked onions are far more toxic on a per weight basis than raw for the simple fact that as you cook them, they condense. So 1 teaspoon of raw onions does NOT equal 1 teaspoon in cooked onions when you compare toxicity. Once cooked, you are condensing more toxin in a smaller volume.

Garlic can also be a potent cardiac and smooth muscle relaxant, dilate blood vessels and lead to hypotension. Both onions and garlic can be potent anti-thrombic agents: they prevent clot formation. So it really wouldn't be a great idea for you to give your big Labrador 3 or 4 cloves of garlic to boost his immune system on the morning he's going in for a fracture repair. This actually happened to one of my colleagues. They found out that there was a problem when they were shaving the dog for surgery and the skin started to ooze blood. That is NOT NORMAL! If they would have continued with the surgery, there could have been fatal consequences.

Baby food used to have onion powder in it and believe it or not it was one of the most toxic concentrations for animals if they were fed that long term. Lucky for us, most of the baby food companies have stopped putting it in there and veterinary hospitals can continue to use these foods to help entice finicky patients to get back to eating.  Why doesn't it affect humans the same way as it does animals? Our red blood cells are a heck of a lot more resilient than the dogs and even more so than the cat.  Cats if you haven't already figured out are just a whole other story all together! Every thing affects them to the nth degree more than any other species and in fact can kill them all that much faster too.

Jaundiced gums and lips of a cat
What signs would you see if your pet has ingested enough garlic or onions to make them clinically sick? Weakness, increased respiratory rate, increased heart rate, and very dark urine. You may even see jaundice or a yellow color to the gums, inside of the ears, all of the skin, and the whites of the eyes. Laboratory abnormalities that would show up would be very low PCV (red blood count), hemoglobinuria (why the urine has the dark color), hemoglobinemia (large amounts of hemoglobin free in the blood stream and not inside the red blood cells), red blood cell abnormality called Heinz Body anemia. What that last part is describing is a small accumulation of hemoglobin that had been denatured and it sticks to other red blood cells. These cells are recognized by the body as foreign and then marked for destruction by the spleen. If enough of these cells are destroyed, you get the low red cell count...anemia.

Take Home Message

While the small amount of garlic in pet foods made commercially and those in veterinary approved home cooked recipes can stimulate some of the changes biological changes listed above, it usually will NOT cause the hemolytic disorders in an otherwise healthy pet. It's when people start supplementing themselves using more than recommended by their veterinarians. This can be done by using additional raw garlic bulbs, but more so using the powders and dehydrated forms of onions.  More in these cases is definitely not better!

Toxicity can be cumulative in these over-supplemented cases because the body doesn't have enough time to destroy the affected cells and also produce new red blood cells before even more are destroyed.  

So instead of perpetuating the Old Wive's Tales, please, please PLEASE have these discussions with your own veterinarians to help you develop the best health care routine for your pets. Trust me, we would want to be proactive in your pet's health than have to see you on an emergency at 3am and have to tell you what you've been feeding your pet caused it's current illness. 

Some links you'll want to bookmark

Click here to go to the site


ASPCA POISON CONTROL


See you next week for another segment on common toxicities in pets.
~Dr. Tammy

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